The Interdependence of Scientists in the Era of Team Science: An Exploratory Study Using Temporal Network Analysis

How is the rise in team science and the emergence of the research group as the fundamental unit of organization of science affecting scientists’ opportunities to collaborate? Are the majority of scientists becoming dependent on a select subset of their peers to organize the intergroup collaborations that are becoming the norm in science? This dissertation set out to explore the evolving nature of scientists’ interdependence in team-based research environments. The research was motivated by the desire to reconcile emerging views on the organization of scientific collaboration with the theoretical and methodological tendencies to think about and study scientists as autonomous actors who negotiate collaboration in a dyadic manner. Complex Adaptive Social Systems served as the framework for understanding the dynamics involved in the formation of collaborative relationships. Temporal network analysis at the mesoscopic level was used to study the collaboration dynamics of a specific research community, in this case the genomic research community emerging around GenBank, the international nucleotide sequence databank. The investigation into the dynamics of the mesoscopic layer of a scientific collaboration networked revealed the following—(1) there is a prominent half-life to collaborative relationships; (2) the half-life can be used to construct weighted decay networks for extracting the group structure influencing collaboration; (3) scientists across all levels of status are becoming increasingly interdependent, with the qualification that interdependence is highly asymmetrical, and (4) the group structure is increasingly influential on the collaborative interactions of scientists. The results from this study advance theoretical and empirical understanding of scientific collaboration in team-based research environments and methodological approaches to studying temporal networks at the mesoscopic level. The findings also have implications for policy researchers interested in the career cycles of scientists and the maintenance and building of scientific capacity in research areas of national interest

The Irr and RirA proteins participate in a complex regulatory circuit and act in concert to modulate bacterioferritin expression in Ensifer meliloti 1021

In this work we found that the bfr gene of the rhizobial species Ensifer meliloti, encoding a bacterioferritin iron storage protein, is involved in iron homeostasis and the oxidative stress response. This gene is located downstream of and overlapping the smc03787 open reading frame (ORF). No well-predicted RirA or Irr boxes were found in the region immediately upstream of the bfr gene although two presumptive RirA boxes and one presumptive Irr box were present in the putative promoter of smc03787. We demonstrate that bfr gene expression is enhanced under iron-sufficient conditions and that Irr and RirA modulate this expression. The pattern of bfr gene expression as well as the response to Irr and RirA is inversely correlated to that of smc03787. Moreover, our results suggest that the small RNA SmelC759 participates in RirA- and Irr-mediated regulation of bfr expression and that additional unknown factors are involved in iron-dependent regulation.Fil: Costa, Daniela. Instituto de Investigaciones Biológicas "Clemente Estable"; UruguayFil: Amarelle, Vanesa. Instituto de Investigaciones Biológicas "Clemente Estable"; UruguayFil: Valverde, Claudio Fabián. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: O`Brian, Mark R.. State University of New York; Estados UnidosFil: Fabiano, Elena. Instituto de Investigaciones Biológicas "Clemente Estable"; Urugua

Findings of the 2019 Conference on Machine Translation (WMT19)

This paper presents the results of the premier shared task organized alongside the Conference on Machine Translation (WMT) 2019. Participants were asked to build machine translation systems for any of 18 language pairs, to be evaluated on a test set of news stories. The main metric for this task is human judgment of translation quality. The task was also opened up to additional test suites to probe specific aspects of translation

Big data analyses reveal patterns and drivers of the movements of southern elephant seals

The growing number of large databases of animal tracking provides an opportunity for analyses of movement patterns at the scales of populations and even species. We used analytical approaches, developed to cope with big data, that require no a priori assumptions about the behaviour of the target agents, to analyse a pooled tracking dataset of 272 elephant seals (Mirounga leonina) in the Southern Ocean, that was comprised of >500,000 location estimates collected over more than a decade. Our analyses showed that the displacements of these seals were described by a truncated power law distribution across several spatial and temporal scales, with a clear signature of directed movement. This pattern was evident when analysing the aggregated tracks despite a wide diversity of individual trajectories. We also identified marine provinces that described the migratory and foraging habitats of these seals. Our analysis provides evidence for the presence of intrinsic drivers of movement, such as memory, that cannot be detected using common models of movement behaviour. These results highlight the potential for big data techniques to provide new insights into movement behaviour when applied to large datasets of animal tracking.Comment: 18 pages, 5 figures, 6 supplementary figure

Comparative transcriptomic analysis of plum fruit treated with 1-MCP

Microarray technology has allowed the large scale transcriptomic analysis of fruit ripening. The μPEACH1.0 microarray containing 4,806 probes corresponding to genes expressed in peach fruit tissues has been used in a heterologous fashion in two studies of plums ripening behavior. Gene expression of different cultivars of plums treated with the ethylene antagonist, 1-methylcyclopropene (1-MCP) and stored for short periods at room temperature or for longer periods of cold storage was examined. In the first study, mature fruit of a suppressed ethylene climacteric cultivar 'Shiro' and a cultivar characterized by a typical increase of ethylene production during ripening ('Santa Rosa') were harvested and incubated for 24h in air (control) or 1-MCP and allowed to ripen at room temperature. Different levels of transcripts of genes implicated in cell wall metabolism, hormone (ethylene and auxin) regulation, stress and defense, and in the transcription/translation machinery, as well as others involved with ripening were identified. In the second study, the effects of 1-MCP on gene expression in relation to the development of chilling injury (CI) in the climacteric cultivars 'Ruby Red' (RR) and 'October Sun' (OS) and 'Zee Lady' peaches (ZP) were analyzed. The fruit were treated for 24h at room temperature with 1-MCP prior to storage at 0°C. For RR, there was no significant effect of 1-MCP on the level of CI symptoms, while 1-MCP significantly reduced CI symptoms in OS fruit and an increase of CI in treated ZP fruit. Microarray analysis showed that immediately following treatment, 186, 134 and 56 genes were differentially expressed between the control and 1-MCP-treated fruit of these cultivars, respectively: after 4 weeks cold storage, 311, 52 and 224 genes for RR, OS and ZP, respectively, were differentially expressed between control and treated fruit. Thus, for OS, the number of differentially expressed genes reduced during storage while the number increased in RR and ZP. Comparisons of the data suggest that the transcript profile is altered by 1-MCP more in plums than peaches. These studies, carried out within an international collaborative network, will increase our understanding of the regulation of pathways involved in plum fruit ripening and in metabolic processes related to storage and shelf lif

Mapping the CMB II: the second flight of the QMAP experiment

We report the results from the second flight of QMAP, an experiment to map the cosmic microwave background near the North Celestial Pole. We present maps of the sky at 31 and 42 GHz as well as a measurement of the angular power spectrum covering the l-range 40-200. Anisotropy is detected at about 20 sigma and is in agreement with previous results at these angular scales. We also report details of the data reduction and analysis techniques which were used for both flights of QMAP.Comment: 4 pages, with 5 figures included. Submitted to ApJL. Window functions and color figures are available at http://pupgg.princeton.edu/~cmb/welcome.htm

Galactic contamination in the QMAP experiment

We quantify the level of foreground contamination in the QMAP Cosmic Microwave Background (CMB) data with two objectives: (a) measuring the level to which the QMAP power spectrum measurements need to be corrected for foregrounds and (b) using this data set to further refine current foreground models. We cross-correlate the QMAP data with a variety of foreground templates. The 30 GHz Ka-band data is found to be significantly correlated with the Haslam 408 MHz and Reich and Reich 1420 MHz synchrotron maps, but not with the Diffuse Infrared Background Experiment (DIRBE) 240, 140 and 100 micron maps or the Wisconsin H-Alpha Mapper (WHAM) survey. The 40 GHz Q-band has no significant template correlations. We discuss the constraints that this places on synchrotron, free-free and dust emission. We also reanalyze the foreground-cleaned Ka-band data and find that the two band power measurements are lowered by 2.3% and 1.3%, respectively.Comment: 4 ApJL pages, including 4 figs. Color figures and data at http://www.hep.upenn.edu/~angelica/foreground.html#qmap or from [email protected]

Aircraft Conceptual Design Using Vehicle Sketch Pad

Vehicle Sketch Pad (VSP) is a parametric geometry modeling tool that is intended for use in the conceptual design of aircraft. The intent of this software is to rapidly model aircraft configurations without expending the expertise and time that is typically required for modeling with traditional Computer Aided Design (CAD) packages. VSP accomplishes this by using parametrically defined components, such as a wing that is defined by span, area, sweep, taper ratio, thickness to cord, and so on. During this phase of frequent design builds, changes to the model can be rapidly visualized along with the internal volumetric layout. Using this geometry-based approach, parameters such as wetted areas and cord lengths can be easily extracted for rapid external performance analyses, such as a parasite drag buildup. At the completion of the conceptual design phase, VSP can export its geometry to higher fidelity tools. This geometry tool was developed by NASA and is freely available to U.S. companies and universities. It has become integral to conceptual design in the Aeronautics Systems Analysis Branch (ASAB) here at NASA Langley Research Center and is currently being used at over 100 universities, aerospace companies, and other government agencies. This paper focuses on the use of VSP in recent NASA conceptual design studies to facilitate geometry-centered design methodology. Such a process is shown to promote greater levels of creativity, more rapid assessment of critical design issues, and improved ability to quickly interact with higher order analyses. A number of VSP vehicle model examples are compared to CAD-based conceptual design, from a designer perspective; comparisons are also made of the time and expertise required to build the geometry representations as well

Probability Density of the Multipole Vectors for a Gaussian Cosmic Microwave Background

We review Maxwell's multipole vectors, and elucidate some of their mathematical properties, with emphasis on the application of this tool to the cosmic microwave background (CMB). In particular, for a completely random function on the sphere (corresponding to the statistically isotropic Gaussian model of the CMB), we derive the full probability density function of the multipole vectors. This function is used to analyze the internal configurations of the third-year Wilkinson Microwave Anisotropy Probe quadrupole and octopole, and we show the observations are consistent with the Gaussian prediction. A particular aspect is the planarity of the octopole, which we find not to be anomalous.Comment: 12 pages, 7 figures, MNRAS styl